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"The xCELLigence RTCA SP analysis is without any doubts a proven non-invasive and sensitive method for monitoring the viability, proliferation or migration of cells in real time and thus complements and explains a number of end-point experiments. Our laboratory deals with the study of new natural molecules or compounds prepared semisynthetically. The analysis software is also intuitive and complete, moreover, ACCELA as a local supplier is able to provide qualified training and service."

Dr Darja Koutová

Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic

"I used the xCELLigence DP system to study the effectiveness of CAR-T against target cancer cells. I was able to observe the effectiveness of cell therapy during the entire experiment with great accuracy. Both devices and software are easy and pleasant to use”

Dr Anna Bujak, Principal Research Scientist

Helix Immuno-Oncology, Warsaw, Poland

"The iCELLigence system provides me a fast, reliable and reproducible way to specifically monitor the suspension cell interactions with proteins of the extracellular matrix, and dynamics of its changes in response to inhibitor addition”

Dr. Adam Obr

Institute of Hematology and Blood Transfusion, Prague, Czech Republic

"By skipping the guesswork associated with end-point assays and eliminating the time- and labor-intensive steps of traditional cell-based assays, real-time cell analysis with the xCELLigence RTCA DP vastly improves efficiency and overall productivity. By eliminating the need for labels/dyes, the physiological relevance of acquired data is maximized"

Dr. Veréb Zoltán

Faculty of Medicine, University of Szeged, Hungary

"xCELLigence system helped my research in performing real-time evaluation of the toxicological profile for several types of innovative drugs that were tested on both primary cells and standard cell lines. Additionally, this platform demonstrated high sensitivity of detection of intracellular signaling events for drugs targeting protein kinases-mediated cellular pathways."

Dr. Monica Neagu

'Victor Babeș' National Institute of Pathology, Bucharest, Romania

xCELLigence DP - Agilent technologies

The technology extended into most powerful cell migration tool

The RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16.It is located inside a tissue culture incubator. Each of the three 16-well plate holders can be used independently under the RTCA Software. The RTCA DP Analyzer can automatically select wells for measurement and continuously transfer measured impedance data to the computer. Cell Index values, derived from the measured impedances, are continuously displayed on the Software user interface.

The RTCA DP Instrument is composed of three main components: 

  • RTCA DP Analyzer
  • RTCA Control Unit
  • E-Plate 16 or CIM-Plates 16

RTCA DP Instrument Highlights: 

  • Highly flexible low throughput: Accommodates up to three E-Plates 16 or CIM-Plates 16 simultaneously
  • Flexibility: Independent operation of the three 16 well plates by up to three different users
  • Clear data presentation: 16-well graph shows individual Cell Index curves for all 16 wells
  • Broad range of applications for cellular assays and cell invasion migration assays

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https://www.aceabio.com/products/rtca-dp/

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Cancer Immunotherapy Applications of xCELLigence Real-Time Cell Analysis (RTCA) Systems Use of the real time xCelligence system for purposes of medical microbiology xCELLigence cancer immunotherapy: NK cell-mediated cytolysis In vitro hypoxia studies using xCELLigence platform Real-time chemotaxis of macrophages Quantifying virus-mediated cytopathic effect with xCELLigence platform Introducing the xCELLigence Immunotherapy kit – B Cell killing assay Real-time monitoring of Human Skin-Derived Precursor (SKPs) cell differentiation Assessment of CAR T Cell killing capacity against solid tumors-Thursday, October 20, 2016, 5 pm CEST Cancer immunotherapy: Macrophage-mediated phagocytosis Monitoring in real time the formation and removal of biofilms from clinical related pathogens xCELLigence in personalized cancer medicine Investigating the hallmarks of cancer using xCELLigence system Monitoring the formation and removal of biofilms from clinically relevant pathogens in real-time Real-time determination of virus titers using cell electric impedance technology Label-free monitoring of T cell activation by the impedance-based system A novel high throughput assay for diagnosis by real-time monitoring of parasite motility Optimization of (CAR) T cell design guided by sensitive sssessment of B cell killing Cellular impedance measurement- novel method for in-vitro investigation of drug efficacy Cellular impedance measurement- response of OVCAR-3 cells to Cisplatin and hyperthermia Automated continuous monitoring of growth factor-mediated Endothelial cell migration ACEA webinar series: Using xCELLigence RTCA to study biofilms formation Protectome analysis: A new selective tool for bacterial vaccine discovery Kinase study of cytotoxicity voted paper of the year.
Katarzyna Nazarewicz

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Katarzyna

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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