Discover
Related topics
Webinar recording: Deep dive into Spatial Biology with MERSCOPE Ultra Platform
Aug 16, 2024
We invite you to learn more about MERSCOPE Ultra Platform. Webinar featuring Rob Mathis (Global Instrument Product...
Single-Cell Genomics applications ? Ideal work for the WOLF gentle cell sorter
Aug 2, 2024
The field of genomics and computational biology has progressed immensely over the last decade and new single-cell...
Study finds that automated liquid-handling operations are more robust, resilient, and efficient!
Jul 18, 2024
Liquid handling devices (LHD) improve lab efficiency and accuracy. They automate liquid transfers, increase experiment...
Scaling Whole-Genome Sequencing to >50,000 single cells using cellenONE
Jul 16, 2024
cellenONE technology enabled the creation of tens of thousands of high-quality single-cell genomes, paving the way for...
Theranostics: From Mice to Men and Back
Jun 25, 2024
Recorded webinar
Presenters: Prof. Dr. Ken Herrmann and Prof. Dr. Katharina Lückerath – Moderator: Hannah Notebaert
Orion 2024 AACR poster: 17-plex single-step stain and imaging of cell Lung Carcinoma
Jun 21, 2024
RareCyte Orion is a benchtop, high resolution, whole slide multimodal imaging instrument. A combination of quantitative...
Automated Purification of Viral DNA and RNA from Biological Samples usingZymo Research Quick-DNA/RNA
Jun 14, 2024
The Quick DNA/RNA Viral MagBead Kit from Zymo has been automated with the Cybio FeliX pipetting robot from Analytik...
DNA Amplicon Library Preparation for Illumina® Sequencing
Jun 12, 2024
The precision of temperature control, efficient heating and cooling rates, and excellent temperature homogeneity across...
X-RAD 320 for irradiation therapy during quantifying study for in vivo collagen reorganization
Jun 5, 2024
Quantifying in vivo collagen reorganization during immunotherapy in murine melanoma with second harmonic generation...
Exosome-Mediated Delivery of Small Molecules, RNA & DNA for Development of Novel Cancer Therapeutics
Jun 3, 2024
Disha Moholkar of University of Louisville's Gupta Lab
Tuesday, June 11, 2024, 6:30 PM...
Dec 19, 2018
Researchers investigated the platelet-independent interaction between stressed erythrocytes and ULVWFs and its consequences for microcirculation and organ function under dynamic conditions. In response to shear stress, erythrocytes interacted strongly with VWF to initiate the formation of ULVWF/erythrocyteaggregates via the binding of Annexin V to the VWF A1 domain. VWF-erythrocyte adhesion was attenuated by heparin and the VWF-specific protease ADAMTS13. In an in vivo model of renal ischemia/reperfusion injury, erythrocytes adhered to capillaries of wild-type but not VWF-deficient mice and later resulted in less renal damage. In vivo imaging in mice confirmed the adhesion of stressed erythrocytes to the vessel wall. Moreover, enhanced eryptosis rates and increased VWF binding were detected in blood samples from patients with chronic renal failure. Our study demonstrates that stressed erythrocytes have a pronounced binding affinity to ULVWFs. The discovered mechanisms suggest that erythrocytes are essential for the pathogenesis of microangiopathies and renal damage by actively binding to ULVWFs.
Brand profile
With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Cell Microsystems turn power of benchtop cellular analysis with advanced tools to automate complex assays.
More info at:
https://cellmicrosystems.com
