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Nov 26, 2021
The IsoLight platform’s predictive single-cell response enables quality assessments of T cell immunotherapies, as well as improved assessment of clinical response and mechanism of action in patient samples.Toxicity, low or no response, and relapse are major challenges of immune-based cancer therapies faced on both manufacturing and clinical development pathways toward success in patient outcome. Confounding factors with respect to specifications for toxicity and potentially lethal side effects in chimeric antigen receptor (CAR) T cell therapies are related to the complex functional responses of these engineered T cells. Isoplexis provides actionable potency, safety, and patient-difference metrics by assessing deep T cell functional response in patients, accelerating decisions toward clinical success downstream, and enhancing scalability
Related technologies: Functional biology
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Systems, which drive convergence of dynamic proteomics and single cell biology for the first time, are creating this deeper connection to accelerate curative medicines.
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https://isoplexis.com
