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Pretargeted delivery of PI3K/mTOR small-molecule inhibitor–loaded nanoparticles

Jul 3, 2021

Non-Hodgkin’s lymphoma (NHL) is one of the most common types of hematologic malignancies in the United States. In 2018, 75,000 Americans were newly diagnosed with NHL, and an estimated 20,000 died from it. Anti-CD20 (α-CD20) monoclonal antibodies (Abs), such as rituximab, have revolutionized the treatment of NHL, but 35 to 40% of patients with NHL still relapse after rituximab-containing therapy, such as R-CHOP. Some data indicate that low antigen density, antigen shedding, and/or internalization of CD20 antigens in malignant lymphoma cells could be responsible for resistance to rituximab. For this reason, Abs that target other common lymphoma markers have been investigated.

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