Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.
Automated microscopy and Spatial Proteomics
Automated microscopy and image analysis
Discover
Back to filter
Show all topics (10)
Related topics
Theranostics: From Mice to Men and Back
Jun 25, 2024
Recorded webinar
Presenters: Prof. Dr. Ken Herrmann and Prof. Dr. Katharina Lückerath – Moderator: Hannah Notebaert
Orion 2024 AACR poster: 17-plex single-step stain and imaging of cell Lung Carcinoma
Jun 21, 2024
RareCyte Orion is a benchtop, high resolution, whole slide multimodal imaging instrument. A combination of quantitative...
Automated Purification of Viral DNA and RNA from Biological Samples usingZymo Research Quick-DNA/RNA
Jun 14, 2024
The Quick DNA/RNA Viral MagBead Kit from Zymo has been automated with the Cybio FeliX pipetting robot from Analytik...
DNA Amplicon Library Preparation for Illumina® Sequencing
Jun 12, 2024
The precision of temperature control, efficient heating and cooling rates, and excellent temperature homogeneity across...
X-RAD 320 for irradiation therapy during quantifying study for in vivo collagen reorganization
Jun 5, 2024
Quantifying in vivo collagen reorganization during immunotherapy in murine melanoma with second harmonic generation...
Exosome-Mediated Delivery of Small Molecules, RNA & DNA for Development of Novel Cancer Therapeutics
Jun 3, 2024
Disha Moholkar of University of Louisville's Gupta Lab
Tuesday, June 11, 2024, 6:30 PM...
Emulate in vivo conditions – introduce shear flow to your experiments with BioFlux system
May 27, 2024
Most research is still conducted in vitro without the presence of flow. We use the BioFlux System to give you the...
High-frequency Ultrasound System For Preclinical Imaging
May 13, 2024
The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging...
April 2024 publication revealing benefits of using intravital microscopy in trascriptomics studies
May 7, 2024
Transcriptional activation of Bmal1 drives the inflammatory activity of monocytes by modulating mitochondrial unfolded...
Omics Studies of Tumor Cells under Microgravity Conditions
May 6, 2024
It is important for the analysis of data from space experiments to distinguish unspecific stress reactions from...
Kinase study of cytotoxicity voted paper of the year.
Jun 6, 2018
Use of kinase inhibitors (KI) for therapeutic purposes is limited by their cardiotoxicity. Therefore, further design of new KIs further understanding is required. In the human genome there are over 500 kinases present. The binding site for ATP is quite conserved between them creating polypharmacology. Because kinases show flexibility in binding across the kinome, researchers in this study have assesed the effects on cardomyocyte beating. After this high throuhput analysis 30 of the inicial 65 kinases were deemed to have met the criteria of having pharmacological inhibition, expression in both human induced pluripotent stem cell-derived cardiomyocytes and adult heart tissue, and effect on cardomyocyte beating following single gene knockdown. These kinases were then chosen for a mechanistic study.
The xCELLigence system was used to predict cytotoxicity hazards in the study. To quote:
"Impedance-based assays with hiPSC CM have proven highly predictive for each of the leading functional cardiotoxicity hazards including arrhythmia (hERG and non-hERG related), chronotropy, inotropy, and KI induced functional cardiotoxicity"
Brand profile