Syncell developed a method combining microscopy, photo-biotinylation, and mass spectrometry, enabling high-resolution mapping of proteins in subcellular regions, accelerating discoveries in spatial proteomics research.
miR-185-5p Derived From hUC-MSC Exosomes via Suspension Culture Under Hypoxic Conditions Promotes Scarless Wound Healing in Mice by Precisely Regulating Collagen I/III Regeneration
Rats are increasingly valued for intravital imaging due to their larger body size and organ systems, which enable more precise surgical preparation, stable window implantation, and repeated long-term imaging - advantages over mice.
Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age-Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice
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Findings suggest that distinct genomic features, tumor states, and microenvironments differentiate ICB response and progression in MM, highlighting key tumor-intrinsic and microenvironmental factors associated with prognosis.
Probiotics, particularly strains of lactic acid bacteria (LAB), are recognized for their beneficial effects on gut health. Lactobacillus acidophilus L177, a promising probiotic strain isolated from canine feces, was evaluated for safety and probiotic.
This application note demonstrates the compatibility of spheroONE and GrowDex® to automate 3D cell culture workflows. spheroONE is a nanoliter dispenser enabling sorting and isolation of spheroids and organoids.
T-cell exhaustion contributes to immunotherapy failure in chronic lymphocytic leukemia (CLL). T cells from CLL patients' blood, bone marrow, and lymph nodes were analyzed using single-cell RNA sequencing, mass cytometry, and tissue imaging.
This study not only highlights the use of spheroids for mechanistic toxicological studies but also provides a framework for identifying potential metabolic biomarkers of PAH exposure. Use of ClinoStar for hepatic HepG2 spheroids made the difference !
This study investigates the therapeutic and immunological effects of combining Radium-223 dichloride (Xofigo) with immune checkpoint inhibitors (ICIs) in a clinically relevant, immunocompetent murine model of prostate cancer bone metastasis.
Discover how Microscoop®, APEX2, and BioID offer unique advantages for mapping protein-protein interactions—whether in fixed tissue or live cells. Learn which method fits your proteomics research best!
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - peer-reviewed paper outlines aging-related changes in white matter by single-cell and spatial transcriptomics