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Functional cure with single agent olutasidenib in relapsed IDH1/NPM1 co-mutated AML
This case report by Justin Watts and colleagues describes a patient with relapsed acute myeloid leukemia (AML) harboring IDH1 and NPM1 mutations who achieved a functional cure using olutasidenib alone — an oral, selective mIDH1 inhibitor.
August 20, 2025
Incorporation of SARS-CoV-2 spike NTD to RBD protein vaccine improves immunity against viral variant
By fusing the spike protein's terminal domain (NTD) with its receptor-binding domain (RBD), researchers have engineered a protein vaccine that significantly amplifies both T-cell responses and antibody breadth.
June 25, 2025
Control of behavioral uncertainty by divergent frontal circuits
Preprint on bioRxiv shows that plasma p-tau181, NfL, and GFAP effectively differentiate Alzheimer’s from FTD and DLB, while Aβ₁₋₄₂/₁₋₄₀ adds little diagnostic value.
June 4, 2025
High-throughput, physiological assays of leukocyte adhesion and rolling
BioFlux shear flow systems enable the visualization and analysis of all of the steps of the leukocyte adhesion cascade under physiological/pathological shear flow using one system.
April 4, 2025
A comprehensive comparison on clustering methods for multi-slide spatially resolved transcriptomics
This study evaluates clustering methods for multi-slide spatial transcriptomics (ST) data, analyzing preprocessing techniques like PASTE and Harmony to guide method selection.
March 19, 2025
Change in Enlarged Perivascular Spaces over Time and Associations with Outcomes After Brain Injury
The goal of this study was to identify MRI burden of EPVs over time following TBI and to explore their relationship with postinjury outcomes.
March 3, 2025
Growing Mature Biofilms for Antimicrobial Screening, Host-pathogen Interactions, and Adhesion
We present the BioFlux shear flow system, a microfluidic flow cell array that enables the growth of biofilms in precisely controlled conditions, including shear stress, temperature, and environmental gas.
June 18, 2025
Curious how PET imaging and reporter gene tracking are transforming CAR-T cell therapy in oncology?
Recorded webinar is recommended if you are working or you are interested by translational studies in oncology, immune therapy, and biomedical imaging.
June 2, 2025
Protocol for simultaneous isolation of high-quality & high-quantity cardiomyocytes and non-myocytes
A protocol to simultaneously isolate high-quality and high-quantity cardiomyocytes and non-myocyte cells, including immune cells, from adult rat hearts. Detailed procedures for viability analysis and cell type identification using Wolf sorter.
March 28, 2025
Optimizing Substrate Dosing for Reliable Bioluminescence Imaging (BLI)
Best Practices for Substrate Dosing: dose based on weight, prepare fresh solutions, use standardized routes of administration and more
March 17, 2025
1568 Single-Cell Multi-Omic Analysis of AML MRD Reveals Differences in Clonal Architecture
The Mission Bio AML single-cell MRD assay quantitatively characterizes SNVs and surface protein expression simultaneously across thousands of individual cells. In contrast, bulk NGS requires averaging across the entire population.
February 28, 2025
Differential diagnostic performance of a panel of plasma biomarkers for different types of dementia
This study assesses a plasma biomarker panel (p-tau181, NfL, GFAP) for differentiating Alzheimer’s, FTD, and DLB, showing high accuracy, while Aβ₁₋₄₂/₁₋₄₀ ratio adds limited value.
June 9, 2025
Serum neurofilament measurement improves clinical risk scores for outcome prediction.
A recent study found serum neurofilament light chain (NfL) levels to be strongly associated with poor neurological outcome in patients after cardiac arrest. Our aim was to confirm these findings in an independent validation study.
April 16, 2025
Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice.
Here we report, in the MRL/lpr SLE model, unexpected heterogeneity among ABC-like cells for expression of the integrins CD11b and CD11c, T-bet, and memory or plasmablast markers.
March 21, 2025
Maximize results and efficiency of Analytik Jena equipment in your NGS workflow with new ebook
This e-book shows how important NGS sample preparation is for high-quality sequencing results and how it can be simplified and optimized.
March 4, 2025