Technologies for omics research

This large-scale study analyzed over 137,000 single nuclei from 24 pancreatic neoplasms. High-throughput snDNA-seq revealed higher driver gene alteration frequencies and more complex clonal trajectories than bulk sequencing.

A study of 326 older adults revealed that prolonged sleep and later wake times accelerate cognitive decline in those with Alzheimer’s pathology. Quanterix’s ultra-sensitive Simoa technology was essential for plasma p-tau217 detection.

Combining IP-MS with Syncell optoproteomics reveals how the NLRP3 inflammasome dynamically reorganizes its protein interaction network and identifies a novel regulatory mechanism.