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Optimizing Substrate Dosing for ReliableBioluminescence Imaging (BLI)
Bioluminescence imaging relies on precise D-luciferin administration, as dosing variability impacts signal intensity and data consistency. Standardizing substrate delivery is essential for reproducible and high-quality in vivo imaging results.
September 18, 2025
Image-activated cell sorting
The NanoCellect VERLO Image-Guided Cell Sorter is mentioned in the attached Nature Reviews Bioengineering paper (Ding et al., 2025) reviewing commercially available Image-Activated Cell Sorting systems.
September 16, 2025
Functional cure with single agent olutasidenib in relapsed IDH1/NPM1 co-mutated AML
This case report by Justin Watts and colleagues describes a patient with relapsed acute myeloid leukemia (AML) harboring IDH1 and NPM1 mutations who achieved a functional cure using olutasidenib alone — an oral, selective mIDH1 inhibitor.
August 20, 2025
Incorporation of SARS-CoV-2 spike NTD to RBD protein vaccine improves immunity against viral variant
By fusing the spike protein's terminal domain (NTD) with its receptor-binding domain (RBD), researchers have engineered a protein vaccine that significantly amplifies both T-cell responses and antibody breadth.
June 25, 2025
Differential diagnostic performance of a panel of plasma biomarkers for different types of dementia
This study assesses a plasma biomarker panel (p-tau181, NfL, GFAP) for differentiating Alzheimer’s, FTD, and DLB, showing high accuracy, while Aβ₁₋₄₂/₁₋₄₀ ratio adds limited value.
June 9, 2025
Control of behavioral uncertainty by divergent frontal circuits
Preprint on bioRxiv shows that plasma p-tau181, NfL, and GFAP effectively differentiate Alzheimer’s from FTD and DLB, while Aβ₁₋₄₂/₁₋₄₀ adds little diagnostic value.
June 4, 2025
Subcutaneous delivery of MSC induces immunoregulatory effects in the lymph node
Mice were imaged under anaesthesia (2.5% isoflurane in oxygen), daily until the bioluminescence signal disappeared. Imaging was performed in an Ami-HTX Small Animal Imager and analysed with Aura Imaging Software, from Spectral Instruments Imaging.
September 12, 2025
Applications: Phase Contrast and Fluorescence Microscopy
Phase contrast and fluorescence microscopy reveals structural and molecular details in cells. Lumascope microscopes are ideally suited for research that requires both, for example this cancer-related study.
August 18, 2025
Growing Mature Biofilms for Antimicrobial Screening, Host-pathogen Interactions, and Adhesion
We present the BioFlux shear flow system, a microfluidic flow cell array that enables the growth of biofilms in precisely controlled conditions, including shear stress, temperature, and environmental gas.
June 18, 2025
Spatial Proteomics: Charting the Protein Landscape in Tissues
Spatial proteomics uncovers the spatial distribution of proteins within tissues, enabling detailed analysis of cellular functions, disease progression, and intercellular interactions beyond the limits of traditional bulk proteomic approaches.
June 6, 2025
How to Make Membrane Protein Research Less Frustrating?
What if studying membrane proteins didn’t have to be so hard? Discover how a breakthrough technique is making fragile, complex proteins easier to analyze — no purification, no immobilization, just real results.
June 3, 2025
Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics
The anesthetized mouse was placed on a customized stage for tumor immobilization and colon tumor was exposed to intravital microscopy (IVM-MS2, IVIM Technology, Korea) equipped with 25× water immersion objective.
September 10, 2025
Generating High-Quality cDNA Libraries for Efficient Sequencing of T-cell Receptor mRNA
Single-cell omics provide undiluted information about individual cells, such as transcription levels and sequences of highly variable proteins.Miniaturizing the assay helps scale down analysis to the single-cell level without sacrificing data quality
July 2, 2025
IsoSpark in HIV research: quantitation of proteins in the culture supernatants.
Exciting example of use 22-plex antibody with the IsoPlexis Human Adaptive Immune Panel (Bruker Cellular Analysis) in HIV research.
June 12, 2025
Integrated Biomarker Discovery and T Cell Analysis using the IsoSpark and Beacon Platforms
Bruker’s proteomic barcode and optofluidic technologies synergize to provide researchers with comprehensive understanding of T cell biology.
June 5, 2025