Change in Enlarged Perivascular Spaces over Time and Associations with Outcomes After Brain Injury

This study used 3T MRI sequences to examine the relationship between EPVs and TBI outcomes over 6 months of follow-up. Overall findings revealed that EPVs burden does not change over time after TBI. Higher EPVs at 2 weeks after injury were associated with incomplete recovery at 6 months using a global recovery measure. Further work should continue to investigate the significance of EPVs after TBI to gain better insights into whether this common radiological finding can be used as an imaging biomarker and how EPVs relate to both the underlying pathology, as well as the role in symptomology and clinical recovery following TBI.